Detecting Changes in Intrathoracic Fluid Volume
It is widely believed that improving the subclinical detection of congestion in heart failure patients could substantially reduce the number of hospitalizations.
Fluid volume changes occur earlier than weight changes and other physical symptoms do, and also earlier than impedance changes. Monitoring a patient’s pulse response to a controlled Valsalva maneuver presents an opportunity to act earlier in the progression of heart failure decompensation and possibly inform discharge decisions, treatment interventions and the need for hospitalizations.
The Vixiar Indicor™ detects changes in intrathoracic volume based on the long-understood phenomenon that performing a Valsalva maneuver, a forced expiration against a closed glottis, induces changes in pulse pressure that reflect hemodynamic congestion. The maneuver increases intrathoracic pressure which impedes blood return to the chest, resulting in lower cardiac output and therefore a lower peripheral pulse pressure. However, in patients that are fluid overloaded, the chest is so congested with fluid that impeding blood return by performing a Valsalva will not significantly change cardiac output and thus limb pressure remains largely unchanged. The Indicor utilizes a finger photoplethysmography (PPG) sensor to capture the pulse waveform of the patient at rest and then during the Valsalva. The patient exhales into the Indicor Handheld to create intrathoracic pressure and the system’s software guides the patient through the maneuver and analyzes the patient’s pulse response and outputs the Valsalva Pulse Response, the ratio between minimum amplitude at the end of the Valsalva and the average pulse amplitude at baseline.
The Vixiar Indicor™ is a non-invasive, easy to use, point of care device.
CAUTION: This device is investigational and not for commercial use